Protein Details: Glutamate receptor 3

Function

Ionotropic glutamate receptor that functions as a ligand-gated cation channel; gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA); quisqualic acid; and kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change; leading to the opening of the cation channel; and thereby converts the chemical signal to an electrical impulse upon entry of calcium. The receptor then desensitizes rapidly and enters a transient inactive state; characterized by the presence of bound agonist (By similarity). In the presence of CACNG8; shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).

Sequence

PDB Structures

Ligand Binding